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Tandem application of flow cytometry and polymerase chain reaction for comprehensive detection of minimal residual disease in childhood acute lymphoblastic leukemia

✍ Scribed by Neale, GAM; Coustan-Smith, E; Pan, Q; Chen, X; Gruhn, B; Stow, P; Behm, FG; Pui, C-H; Campana, D


Book ID
110054248
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
109 KB
Volume
13
Category
Article
ISSN
0887-6924

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Patients with acute leukemia in clinical remission may still have up to 10 10 residual malignant cells (the upper limit of detection by standard morphologic techniques). Sensitive techniques to detect minimal residual disease (MRD) may allow better estimates of the leukemia burden and help the selec