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Tamoxifen metabolites as active inhibitors of aromatase in the treatment of breast cancer

✍ Scribed by Wenjie Jessie Lu; Zeruesenay Desta; David A. Flockhart

Publisher
Springer US
Year
2011
Tongue
English
Weight
323 KB
Volume
131
Category
Article
ISSN
0167-6806

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Estrogens are the major hormones supporting the growth of human breast cancer. Aromatization of androgen precursors in peripheral tissues, including the breast cancer itself, is the major source of estrogens in postmenopausal women. Therefore, inhibition of the aromatase enzyme offers an effective m