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Tamoxifen metabolite affected by CYP2D6 polymorphism, inhibitors

Book ID
120854845
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2005
Weight
138 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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CYP2D6 polymorphisms and the impact on t
CYP2D6 polymorphisms and the impact on tamoxifen therapy
โœ Jacob N. Beverage; Tristan M. Sissung; Amy M. Sion; Romano Danesi; William D. Fi ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 122 KB

The cytochrome P450 2D6 (CYP2D6) is an enzyme known to metabolize a variety of xenobiotics and drugs. Inter-individual variation in the metabolic capacity of this enzyme has been extensively studied and associations with genotype have been established. Genetic polymorphisms have been grouped as nonf