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Tamoxifen induces p21WAF1 and p27KIP1 expression in estrogen receptor-negative lung cancer cells

✍ Scribed by Lee, Te-Hsiu; Chuang, Lea-Yea; Hung, Wen-Chun

Book ID
110062179
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
276 KB
Volume
18
Category
Article
ISSN
0950-9232

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## Abstract The cyclin‐dependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30–60 min independent of new protein synthesis in the estrogen recept