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Tamoxifen induced liver mitochondrial toxicity and its mitigation by catechin

✍ Scribed by Heena Tabassum; Suhel Parvez; Basu Dev Banerjee; Sheikh Raisuddin


Book ID
116925600
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
86 KB
Volume
211
Category
Article
ISSN
0378-4274

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Catechin as an antioxidant in liver mito
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## Abstract Tamoxifen (TAM) is a nonsteroidal triphenylethylene antiestrogenic drug widely used in the treatment and prevention of breast cancer. TAM brings about a collapse of the mitochondrial membrane potential. It acts both as an uncoupling agent and as a powerful inhibitor of mitochondrial ele