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Taiwan hospital-based detection of Lynch syndrome distinguishes 2 types of microsatellite instabilities in colorectal cancers

✍ Scribed by Shih-Ching Chang; Pei-Ching Lin; Shung-Haur Yang; Huann-Sheng Wang; Wen-Yih Liang; Jen-Kou Lin

Book ID
113921412
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
430 KB
Volume
147
Category
Article
ISSN
0039-6060

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## Abstract Approximately 1–2% of colorectal cancers (CRC) arise because of germline mutations in DNA mismatch repair genes, referred to as Lynch syndrome. These tumours show microsatellite instability (MSI) and loss of expression of mismatch repair proteins. Pre‐symptomatic identification of mutat