Colorectal Adenomas in Young Patients: Microsatellite Instability is not a Useful Marker to Detect New Cases of Lynch Syndrome

Population-based detection of Lynch synd

Population-based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test

✍ Lyn Schofield; Natasha Watson; Fabienne Grieu; Wei Qi Li; Nik Zeps; Jennet Harve 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 100 KB

## Abstract Approximately 1–2% of colorectal cancers (CRC) arise because of germline mutations in DNA mismatch repair genes, referred to as Lynch syndrome. These tumours show microsatellite instability (MSI) and loss of expression of mismatch repair proteins. Pre‐symptomatic identification of mutat