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Tailoring a low-molecular weight protein tyrosine phosphatase into an efficient reporting protein

✍ Scribed by Xiao-Yan Liu; Lan-Fen Li; Xiao-Dong Su


Book ID
116298421
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
412 KB
Volume
382
Category
Article
ISSN
0006-291X

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The energetics of substrate dephosphorylation in the low-molecularweight protein tyrosine phosphatase is studied with the empirical valence bond method in combination with molecular dynamics free energy perturbation simulations. Different mechanisms corresponding to different charge states of the re