Tablet-to-tablet variation of drug content of sugar-coated tablets containing drug in the sugar coat

✍ Scribed by J. ThurøCarstensen; Arnold Koff; J. B. Johnson; S. H. Rubin

• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 328 KB
• Volume: 59
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600590425

✦ Synopsis

Nevertheless, on acid hydrolysis the compound gave herniarin. The formation of herniarin may be accounted for by the transformation of the liberated 2-hydroxy-4-methoxy-trans-cinnamic acid (IV, Scheme 11) to the cis-form in presence of hydrogen ions. However, enzymatic hydrolysis did not give herniarin but gave 2-hydroxy-4methoxyethyl trans-cinnamate (IV) which was found to be less mobile on paper than herniarin. The structure of the glucoside (I) was also ascertained through its de-ethylation to the free-acid glucoside (111) which was identical in every respect with authentic material prepared synthetically (7). SUMMARY 2-Glucosyloxy-4-methoxyethyl trans-cinnamate was isolated in a crystalline form from the alcoholic extract of Prunus mahaleb L. fruit kernels. The structure of this compound was proved by IR, NMR, and mass spectra. It was further ascertained by de-ethylation of the compound to the free-acid glucoside which was identical with authentic material. On acetylation, it afforded a tetraacetate, the spectral studies of which (IR, NMR, and mass spectra) assured the suggested structure. On acid and enzymatic hydrolysis, it afforded glucose which was identified by chromatographic techniques.

REFERENCES