Application of sugar coating to tablets and confections by means of an automated airless spray system I. Investigation of the direct coating of tablets
✍ Scribed by G. M. Krause; T. L. Iorio
- Publisher
- John Wiley and Sons
- Year
- 1968
- Tongue
- English
- Weight
- 445 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
components with chloroform. However, it is imperative to use 0.01 N NaOH, because a stronger concentration of the base can change the CAF structure (17), and, therefore, cause erratic results.
Automation for the analysis of the four components can be performed by following the above procedures (extraction, rather than differential spectrophotometry is preferred for CAF). The results would be directly obtainable from the responses of the recorders without need of any computers or calculating devices. The proposed schematic diagram for the automated system is shown in Fig. 7.
The tablet is crushed and dissolved in 85% methanolic solution, which is filtered into a central reservoir. From this container, three portions are taken. One aliquot is colorimetrically titrated for ASA in the presence of dye indicator with 0.02 N KOH. A second aliquot is automatically diluted with a given quantity of 0.01 N sodium hydroxide, and the CAF is extracted into chloroform, which is read at 276 mp versus chloroform on a spectrophotometer. A third portion is automatically diluted and separated into two segments. T o one portion, a pH 6 buffer solution is added and passed through a reference flow cell located in a spectrophotometer.
Simultaneously, a pH 10 buffer solution is added to the other segment of the solution and passed through a sample flow cell in the spectrophotometer. The wavelength scale is programmed rapidly to two wavelengths-263.5 and 330 mp. The APAP and SAL are determined at 263.5 and 330 mp, respectively.
The advantage of using these methods is that each specific procedure is independent of the concentrations of the other components, and therefore, can be used either in the presence of large quantities 1223 or in the absence of any of the other ingredients, with very good accuracy and precision.
REFERENCES
(1) Smith, G., J . Assoc. Ofic. Agr. Chemists, 42, 462 (1959).
(2) ':Official and Tentative Methods of Analysis of the Associabon of Agricultural Chemists," 6th ed., Association