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TAB1: An Activator of the TAK1 MAPKKK in TGF-beta Signal Transduction

โœ Scribed by Shibuya, H.; Yamaguchi, K.; Shirakabe, K.; Tonegawa, A.; Gotoh, Y.; Ueno, N.; Irie, K.; Nishida, E.; Matsumoto, K.

Book ID
121156236
Publisher
American Association for the Advancement of Science
Year
1996
Tongue
English
Weight
722 KB
Volume
272
Category
Article
ISSN
0036-8075

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๐Ÿ“œ SIMILAR VOLUMES

TAB2, a Novel Adaptor Protein, Mediates
TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway
โœ Giichi Takaesu; Satoshi Kishida; Atsushi Hiyama; Kyoko Yamaguchi; Hiroshi Shibuy ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 382 KB

The TAK1 MAPKKK mediates activation of JNK and NF-KB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-kappaB activation, whereas a dominant-negativ