T1ρ relaxation and its application to MR histology

✍ Scribed by Robert Thomas Engelhardt; G. Allan Johnson

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 692 KB
• Volume: 35
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910350520

✦ Synopsis

Abstract

The application of T~1__P__~ as an alternative contrast parameter in high‐field magnetic resonance histology (MRH) has been investigated. Spectroscopic measurements of T~1__P__~ were performed on 5.75% agar and 1.0 mM MnCl~2~ phantoms at 9.4 T to validate the accuracy of the imaging measurements. Image studies were performed at 2.0 and 9.4 T on perfusion‐fixed 17.5‐day‐old mouse embryos. T~1′~ T~2′~ and T~1__P__~ relaxation times were calculated for the phantoms and muscle, diencephalon, and liver tissues. The 5.75% agar phantom and all tissues showed T~1__P__~ dispersion with B~1__L__~, whereas the 1.0 mM MnCl~2~ phantom showed no significant B~1__L__~ dependence. T~1__P__~ dispersion with B^0^ was observed arising from the effects of diffusion through susceptibility‐induced gradients. T~1__P__~ shows promise as a contrast parameter in high‐field MRH because it is capable of producing T~2~‐like contrast without the susceptibility artifacts associated with T~2~‐weighted images.