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T1222 NOD2-Mediated Innate Immune Response in Mucosal Biopsies of Children with Active Crohn's Disease

โœ Scribed by Stronati, Laura; Negroni, Anna; Pierdomenico, Maria; Menghi, Ilaria; Maiella, Giulia; Borrelli, Osvaldo; Cucchiara, Salvatore


Book ID
123023774
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
93 KB
Volume
134
Category
Article
ISSN
0016-5085

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โœ Anna Negroni; Laura Stronati; Maria Pierdomenico; Donatella Tirindelli; Giovanni ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 353 KB ๐Ÿ‘ 2 views

Background: NOD2 is an intracellular protein involved in host recognition of specific bacterial molecules and is genetically associated with several inflammatory diseases, including Crohn's disease (CD). NOD2 stimulation activates the transcription factor, NF-B, through RIP2, a caspase-recruitment d