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NOD2/CARD15 and NF-kB expression in mucosal biopsies of children with active Crohn's disease

โœ Scribed by A. Negroni; L. Stronati; P. Merola; V. Pannone; M. Cirulli; O. Borrelli; A. Morley-Fletcher; S. Cucchiara

Book ID
119228306
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
54 KB
Volume
38
Category
Article
ISSN
1590-8658

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## Background: Recent advances in the pathogenesis of Crohn's disease (CD) have suggested that an aberrant innate immune response initiates the cascade of events leading to T-cell activation and to disease development. NOD2 protein, which is mainly expressed by innate immunity cells, appears to pla