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t(11;11)(p13;p15) and high concentration of insulin-like growth factor II in a Wilms' tumor

✍ Scribed by Yasuhide Hayashi; Ryoji Hanada; Keiko Yamamoto; Hiromu Muchi


Book ID
119103796
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
120 KB
Volume
33
Category
Article
ISSN
0165-4608

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Mutations in the WTI tumor suppressor gene are known t o contribute t o the development of Wilms' tumor (WT) and associated gonadal abnormalities. WTI is expressed principally in the fetal kidney, developing gonads, and spleen and also in the mesothelium, which lines the coelomic cavities. These tis