t(11;11)(p13;p15) and high concentration of insulin-like growth factor II in a Wilms' tumor
β Scribed by Yasuhide Hayashi; Ryoji Hanada; Keiko Yamamoto; Hiromu Muchi
- Book ID
- 119103796
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 120 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0165-4608
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract We evaluated the __WT1__ and __IGF2__ status and performed chromosome and/or comparative genomic hybridization analysis in 43 tumor samples from patients with Wilms tumor. On this basis, we classified them into 4 groups: __WT1__ abnormality, loss of heterozygosity (LOH) of __IGF2__, los
## Abstract The most common known molecular defect in Wilms tumor (WT) of the kidney, the most frequent solid tumor of childhood, is loss of imprinting (LOI) of the insulinβlike growth factorβII gene (__IGF2__), which involves activation of the normally silent maternal allele of the gene and hyperm
Mutations in the WTI tumor suppressor gene are known t o contribute t o the development of Wilms' tumor (WT) and associated gonadal abnormalities. WTI is expressed principally in the fetal kidney, developing gonads, and spleen and also in the mesothelium, which lines the coelomic cavities. These tis