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T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor

✍ Scribed by Adrian Handforth; Gregg E. Homanics; Douglas F. Covey; Kathiresan Krishnan; Jae Yeol Lee; Kenji Sakimura; Fredricka C. Martin; Arnulfo Quesada


Book ID
116785471
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
791 KB
Volume
59
Category
Article
ISSN
0028-3908

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## Abstract Excessive olivo‐cerebellar synchrony is implicated in essential tremor. Because synchrony in some networks is mediated by gap junctions, we examined whether the gap junction blockers heptanol, octanol, carbenoxolone, and mefloquine suppress tremor in the mouse harmaline model, and perfo