𝔖 Bobbio Scriptorium
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T-coffee: a novel method for fast and accurate multiple sequence alignment

✍ Scribed by Cédric Notredame; Desmond G Higgins; Jaap Heringa


Book ID
115630483
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
278 KB
Volume
302
Category
Article
ISSN
0022-2836

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An information theory based multiple alignment ("Malign") method was used to align the DNA binding sequences of the OxyR and Fis proteins, whose sequence conservation is so spread out that it is difficult to identify the sites. In the algorithm described here, the information content of the sequence