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T cells targeted against a single minor histocompatibility antigen can cure solid tumors

✍ Scribed by Meunier, Marie-Christine; Delisle, Jean-Sébastien; Bergeron, Julie; Rineau, Vincent; Baron, Chantal; Perreault, Claude


Book ID
109932768
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
535 KB
Volume
11
Category
Article
ISSN
1078-8956

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CD8^+^ T cells recognizing minor histocompatibility antigens (MiHA) on solid tumor cells may mediate effective graft-versus-tumor (GVT) reactivity after allogeneic stem cell transplantation (SCT). Previously, we identified LRH-1 as a hematopoietic-restricted MiHA encoded by the __P2X5__ gene. Here,