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Potential limitations in using minor histocompatibility antigen-specific cytotoxic T cells for targeting solid tumor cells

✍ Scribed by Mikinori Miyazaki; Yoshiki Akatsuka; Tetsuya Nishida; Nobuharu Fujii; Akio Hiraki; Kazuma Ikeda; Kunio Tsujimura; Kiyotaka Kuzushima; Yasuo Morishima; Shigeki Sato; Ryuzo Ueda; Toshitada Takahashi

Book ID: 117792928
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 148 KB
Volume: 107
Category: Article
ISSN: 1090-2341
DOI: 10.1016/s1521-6616(03)00065-2

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## Abstract We have investigated the role of target cell major histocompatibility complex antigens (MHC‐Ag) in nonspecific lectin‐dependent lymphocyte‐mediated cytolysis (LDCC). In contrast to previous reports, we provide evidence that in LDCC the lectin Concanavalin A (Con A) does not mediate lysi