T Cells and Natural Killer Cells Regulate Human IgG Subclass Concentrations in SCID Mice
β Scribed by Donna M. Ambrosino; Michael Wang; Angela Ciamarra; Melvin Chan; David L. Bolon; Juno Minn; David A. Jacobsohn; Robert W. Finberg
- Book ID
- 112238948
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 342 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0008-8749
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Natural killer T (NKT) cells and regulatory T cells (Tregs) are both found within the liver and are known to exhibit immune regulatory functions. Hepatic NKT cells are activated early during inflammatory responses and release cytokines, including interferon gamma (IFN-β₯), which we speculated could r
## Abstract Lupusβprone NZB/W F1 mice develop glomerulonephritis after Tβhelper cellβdependent isotype switching of autoantibody secretion from IgM to IgG at about 6βmonths of age. We compared innate immune natural killer (NK) T cells and conventional T cells for their capacity to help spontaneous