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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

✍ Scribed by Kägi, David; Ledermann, Birgit; Bürki, Kurt; Seiler, Peter; Odermatt, Bernhard; Olsen, Kristin J.; Podack, Eckhard R.; Zinkernagel, Rolf M.; Hengartner, Hans

Book ID
109788464
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
885 KB
Volume
369
Category
Article
ISSN
0028-0836

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## Abstract Lymphocytes from normal mice were found to have cell‐mediated cytotoxicity, in a short‐term ^51^Cr release assay, against a variety of non‐lymphoid tumor cells as well as against lymphomas. Some of the non‐lymphoid tumors were as susceptible to natural cytotoxicity as the standardly use