## Abstract ## Background: Zeta‐chain associated protein of 70kDa (ZAP‐70) is the most promising surrogate marker for the immunoglobulin heavy chain variable region (IgV~H~) mutation status in B‐cell chronic lymphocytic leukemia (B‐CLL). Crespo et al. proposed the detection of ZAP‐70 by flow cytom
T-cell ZAP-70 overexpression in chronic lymphocytic leukemia (CLL) correlates with CLL cell ZAP-70 levels, clinical stage and disease progression
✍ Scribed by Herishanu, Y; Kay, S; Rogowski, O; Pick, M; Naparstek, E; Deutsch, V R; Polliack, A
- Book ID
- 110056284
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 98 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0887-6924
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## Abstract Among 14 peripheral blood samples obtained from patients affected by B chronic lymphocytic leukemia (B‐CLL) at initial stages (Rai 0–1) of the disease, 6 showed intermediate/high levels of Zap‐70 while 8 displayed low/absent levels of Zap‐70. Although Zap‐70^high^ and Zap‐70^low^ B‐CLL
## Abstract ## Background: Expression of T cell specific zeta‐associated protein 70 (ZAP‐70) by B‐cell chronic lymphocytic leukemia (B‐CLL) cells, as investigated by flow cytometry, has both prognostic relevance and predictive power as surrogate for immunoglobulin heavy chain variable region (IgV~