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T-cell tolerance and autoimmunity to systemic and tissue-restricted self-antigens

✍ Scribed by Jens Lohr; Birgit Knoechel; Vijaya Nagabhushanam; Abul K. Abbas


Book ID
110746588
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
146 KB
Volume
204
Category
Article
ISSN
0105-2896

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## Abstract Induction of T cell tolerance in the thymus (central tolerance) is essential for preventing organ‐specific autoimmunity. This apparent paradox is in part explained by promiscuous expression of numerous tissue‐restricted self‐antigens (TRA) in medullary thymic epithelial cells (mTEC), wh