Highly variable expression of tissue-res
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Richard Taubert; Jochen Schwendemann; Bruno Kyewski
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Article
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2007
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John Wiley and Sons
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English
β 283 KB
## Abstract Induction of T cell tolerance in the thymus (central tolerance) is essential for preventing organβspecific autoimmunity. This apparent paradox is in part explained by promiscuous expression of numerous tissueβrestricted selfβantigens (TRA) in medullary thymic epithelial cells (mTEC), wh