T-cell subsets in autoimmunity

✍ Scribed by Don Mason; Deborah Fowell

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 672 KB
• Volume: 4
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/0952-7915(92)90053-h

✦ Synopsis

The demonstration that functionally different T-cell subsets can be defined by the isoforms of the leukocyte-common antigen, CD45, that they express, has prompted studies on the roles of these subsets in autoimmunity. The results have led to the identification of a particular subset of CD4+ T cells that have the ability to inhibit autoimmune disease. Further, it has been shown that diabetes in the B-B rat can be transferred by in vitro activation of T cells by Staphylococcal enterotoxin suggesting that superantigens may play a role in the pathogenesis of this disease. However, in this system too, it appears that a subset of T cells can inhibit the induction of autoaggressive cells. In other experimental autoimmune diseases there is evidence that CD8+ T cells can be protective and that these cells may mediate this protection by the synthesis of transforming growth factor-beta.