n experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), T helper 1 (Th1)/Th2 immunological effector pathways are altered. Neuropathological findings and results from MS treatment trials suggest that our view of MS and other putative autoimmune diseases and their
β¦ LIBER β¦
T-cell autoimmunity in multiple sclerosis
β Scribed by Reinhard Hohlfeld; Marco Londei; Luca Massacesi; Marco Salvetti
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 376 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0167-5699
No coin nor oath required. For personal study only.
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## Abstract TCR degeneracy may facilitate selfβreactive T cell activation and the initiation of an autoimmune response in multiple sclerosis (MS). MHC classβII alleles of the DR2 haplotype DR2a (DRB5\*0101) and DR2b (DRB1\*1501) are associated with an increased risk for MS in Caucasian populations.
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