✦ LIBER ✦

T-cell responses in photoimmune therapy

✍ Scribed by Peter W. Heald; Hong Yong Kim; Maritza Perez; Richard L. Edelson; Carole L. Berger

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 685 KB
Volume: 10
Category: Article
ISSN: 0733-2459
DOI: 10.1002/jca.2920100309

No coin nor oath required. For personal study only.

✦ Synopsis

The extracorporeal inactivation of a lymphocyte rich buffy coat suspension with ultraviolet A light and 8 methoxypsoralen can lead to dramatic clinical improvements following reinfusion of the damaged cells. This therapy is reviewed in the context of the disease it is most commonly used for: cutaneous lymphoma. Studies with cutaneous lymphoma patients have shown an active immune response against purified tumor cells. In addition a mouse model for an impact of therapy on a T-cell lymphoma has demonstrated results that parallel those from clinical studies in humans. The impact of photoimmune therapy on in vivo and in vitro T-cell responses to cutaneous lymphoma is discussed.

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