T-cell prolymphocytic leukemia with der(11)t(1;11)(q21;q23) and ATM deficiency
β Scribed by Mitsuko Yamaguchi; Koh Yamamoto; Tohru Miki; Shuki Mizutani; Osamu Miura
- Book ID
- 114135629
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 182 KB
- Volume
- 146
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Thirteen cosmid probes were mapped on the long arm of chromosome 11 between 11q22 and 11q24 by nonradioactive in situ hybridization. Starting with these localizations and those of other probes mapped to 11q23, four acute leukemias with translocations involving 11q23 were studied with th
The inv( I4)(q I lq32) is a non-random chromosomal aberration which has been associated with a variety of T-cell malignancies. W e have studied a case of inv( I4)(q I I q32) that is unique in several respects. First, the inversion, which is expressed at the rnRNA level, occurred in the context of a