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T cell proliferation is blocked by indoleamine 2,3-dioxygenase

✍ Scribed by G Frumento; R Rotondo; M Tonetti; G.B Ferrara

Book ID: 117230132
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 526 KB
Volume: 33
Category: Article
ISSN: 0041-1345
DOI: 10.1016/s0041-1345(00)02078-9

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## Abstract ## Background Indoleamine 2,3‐dioxygenase (IDO) is an enzyme involved in the catabolism of tryptophan and has been shown to prevent rejection of the fetus during pregnancy by inhibiting alloreactive T cells. ## Methods In this study we investigated dendritic cells (DCs) that are tran