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Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape

✍ Scribed by Jessica B. Katz; Alexander J. Muller; George C. Prendergast

Book ID: 111248857
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 236 KB
Volume: 222
Category: Article
ISSN: 0105-2896
DOI: 10.1111/j.1600-065x.2008.00610.x

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## Abstract ## Background Indoleamine 2,3‐dioxygenase (IDO) is an enzyme involved in the catabolism of tryptophan and has been shown to prevent rejection of the fetus during pregnancy by inhibiting alloreactive T cells. ## Methods In this study we investigated dendritic cells (DCs) that are tran