Dendritic cells (DC) initiate T cell responses and direct the class of T cell immunity through the production of Th-polarizing cytokines. In the mouse, immunization with CD8alpha(+) DC has led to Th1 priming whereas immunization with CD8alpha(-) DC has been associated with Th2 induction. Here, we us
✦ LIBER ✦
T-cell polarization depends on concentration of the danger signal used to activate dendritic cells
✍ Scribed by Peters, Marcus; Dudziak, Karin; Stiehm, Matthias; Bufe, Albrecht
- Book ID
- 109865981
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 706 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0818-9641
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## Abstract Dendritic cells (DC) are extremely proficient inducers of naïve CD4^+^ T cell activation due to their high expression level of peptide‐MHC and an array of accessory molecules involved in cell migration, adhesion and co‐signaling, including PD‐1 ligand 1 (PD‐L1) and PD‐1 ligand 2 (PD‐L2)
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