T-cell non-hodgkin lymphoma in human immunodeficiency virus-1-infected individuals

✍ Scribed by Dr. John A. Lust; Peter M. Banks; W. Craig Hooper; Carlos V. Paya; Brian D. Kueck; Gerald A. Hanson; Paul S. Ritch; Gayle E. Woloschak

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 687 KB
• Volume: 31
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/ajh.2830310307

✦ Synopsis

We present two patients with human immunodeficiency virus-1 (HIV-1) infection in whom T-cell non-Hodgkin lymphoma developed, based on pathologic diagnosis, immunophenotyping, and T-cell receptor gene rearrangement. Both cases were positive for human immunodeficiency virus-1 by enzyme-linked immunosorbent assay and immunoblot methods. Histologic sections from each patient showed a high-grade pleomorphic T-cell non-Hodgkin lymphoma, and immunophenotyping demonstrated a prevalence of reactivity for CD4 (helper) over CD8 (suppressor) antigens. T-cell receptor p-chain gene rearrangement studies revealed a rearranged pattern with either the Hindlll or BarnHl enzymes, whereas immunoglobulin heavy chain genes retained a germ-line configuration. Viral sequences specific for human T-cell leukemia virus-I, human T-cell leukemia virus-ll, or HIV-1 were not detected. Thus, although rare, T-cell nonHodgkin lymphoma may be observed in HIV-1-infected individuals.