We present two patients with human immunodeficiency virus-1 (HIV-1) infection in whom T-cell non-Hodgkin lymphoma developed, based on pathologic diagnosis, immunophenotyping, and T-cell receptor gene rearrangement. Both cases were positive for human immunodeficiency virus-1 by enzyme-linked immunoso
Cutaneous T-cell lymphoma in a patient infected with human immunodeficiency virus type 1: Use of radiation therapy
โ Scribed by Jeffrey Goldstein; Norwin Becker; John Delrowe; Lawrence Davis
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 888 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0008-543X
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โฆ Synopsis
A patient with cutaneous T-cell lymphoma (CTCL) and acquired immune deficiency syndrome (AIDS) is presented. The patient had a localized lesion on his scalp. Evaluation for systemic lymphoma was negative. A biopsy specimen showed superficial and deep dermal infiltrates of pleomorphic lymphocytes. Immunohistochemistry was consistent with T-cell lymphoma. The patient was treated successfully with local irradiation. He remained free of further systemic and cutaneous recurrences of the lymphoma until he died 8 months after treatment of pneumonia. This case is the first to our knowledge to describe a localized CTCL in a patient infected with human immunodeficiency virus type 1 (HIV-1).
๐ SIMILAR VOLUMES
Adult T-cell leukernidlymphoma (ATL), a malignancy of mature CDCpositive lymphocytes, has been etiologically linked to the human retrovirus HTLV-I. Although a long latent period is suggested from migrant studies, little prospective information on the risk of developing ATL among persons with HTLV-I