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T cell necessity in the pathogenesis of experimental autoimmune encephalomyelitis in mice

โœ Scribed by C. C. A. Bernard; Jennifer Leydon; I. R. Mackay

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
676 KB
Volume
6
Category
Article
ISSN
0014-2980

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Loss of suppressor t cells in the pathog
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โœ Randall S. Krakauer; Warren Strober; Thomas A. Waldmann ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 530 KB

## Loss of suppressor T cells was demonstrated in NZB/W mice, an animal model of autoimmunity. As NZB/W mice matured they lost splenic T cells that could be activated by concanavalin A (Con A) to become sup pressor cells and lost the ability to produce the regulator of humoral immune responses, so