Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis
โ Scribed by Elizabeth P. Blankenhorn; Russell Butterfield; Laure K. Case; Emma H. Wall; Roxana del Rio; Sean A. Diehl; Dimitry N. Krementsov; Naresha Saligrama; Cory Teuscher
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 589 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Mast cells and their potent chemical mediators are known to initiate and modulate a number of important inflammatory cascades. With respect to the central nervous system, the role of mast cells as participants in the promotion and resolution of inflammation has been widely underestimated. Mast cell-
Previous studies of experimental allergic encephalomyelitis (EAE) in the LER rat have suggested that amino acid differences present in the LER TCR Vp8.2 chain may be associated with disease resistance. We report here that LEW rats bred to express a Vp8.2 gene from DA rats, identical to that found in