T-cell-mediated suppression of Epstein-Barr virus-induced B lymphocyte activation in multiple sclerosis
β Scribed by J. Charles Craig; Margaret Haire; J.D. Merrett
- Book ID
- 118374895
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 585 KB
- Volume
- 48
- Category
- Article
- ISSN
- 1090-2341
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Several reports have shown a defective Epstein-Barr virus (EBV)-specific suppressor T cell function in rheumatoid arthritis (RA), suggesting that EBV may have a role in the pathogenesis of RA. EBV-specific T cell regulation was studied in 47 EBV-immune RA patients and in 14 EBV-immune control subjec
## Abstract B lymphocytes separated from antiβHBeβpositive donors were established as lymphoblastoid cell lines by infection with EBV, but antiβHBe in the culture supernatant from such lymphoblastoid cell lines could not be detected. The lymphoblastoid cell lines were rosetted with HBe antigenβcoup