✦ LIBER ✦

T-Cell-Mediated Autoimmunity: Novel Techniques to Characterize Autoreactive T-Cell Receptors

✍ Scribed by Klaus Dornmair; Norbert Goebels; Hans-Ulrich Weltzien; Hartmut Wekerle; Reinhard Hohlfeld

Book ID: 117021678
Publisher: American Society for Investigative Pathology
Year: 2003
Tongue: English
Weight: 886 KB
Volume: 163
Category: Article
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)63481-5

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## Abstract The molecular bases responsible for the loss of T cell tolerance to myelin antigens leading to the onset of multiple sclerosis remain obscure. It has been shown that balanced signaling through activating and inhibitory receptors is critical for the maintenance of tolerance to self antig