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T-cell lineage fate: Instructed by receptor signals?

✍ Scribed by Harald von Boehmer


Book ID
114317824
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
75 KB
Volume
10
Category
Article
ISSN
0960-9822

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MHC specificity in positive selection is a major determinant in the CD4/CD8 T cell lineage decision. Previous studies support the view that quantitative differences in T cell receptor (TCR) signaling in immature CD4 + CD8 + double positive thymocytes leads to an instructive bias in CD4/CD8 T cell li