T-cell function and specificity in athymic mice
โ Scribed by Thomas Hunig
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 442 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0167-5699
No coin nor oath required. For personal study only.
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ollowing Medawarรs landmark experiments in the mouse in the early 1950s (Ref. 1), it became generally accepted that neonatal T cells are uniquely susceptible to tolerance induction. Although direct evidence was difficult to obtain, the idea that human fetuses and neonates were particularly susceptib
## Abstract The adapter protein CrkL has been implicated in multiple signal transduction pathways in hematopoietic cells. In Tโlymphocytes, the recruitment of CrkLโC3G complexes has been correlated with hyporesponsiveness, implicating CrkL as a potential negative regulator. To test this hypothesis