Functional T cell receptor δ chain gene messages in athymic nude mice
✍ Scribed by Yasunobu Yoshikai; Goro Matsuzaki; Yasuyuki Takeda; Shouichi Ohga; Kenji Kishihara; Hiroyuki Yuuki; Kikuo Nomoto
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 822 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0014-2980
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Functional a and p T cell chain receptor messages can be detected in old but not in young athymic mice\* The expression and sequences of T cell antigen receptor (TcR) a and p-chain genes were investigated in the spleens from congenitally athymic (nude) mice. A small number of Thy-1' cells (-7.0%) w
Although the athymic nude mouse is grossly deficient in peripheral T cells, the number of lymphocytes bearing T-cell markers (L3T4, LyT2) and the alpha beta or gamma delta T-cell receptor (Tcr) increases steadily with age. The anatomical site(s) where these cells arise are unknown. Splenocytes from