T-cell development: The right niche for Notch?
β Scribed by Buckland, Jenny
- Book ID
- 109953798
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 179 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1474-1741
- DOI
- 10.1038/nri1035
No coin nor oath required. For personal study only.
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The Notch family of evolutionarily conserved proteins regulates a broad spectrum of cell-fate decisions and differentiation processes during fetal and post-natal development. The best characterized role of Notch signaling during mammalian hematopoiesis and lymphopoiesis is the essential function of
## Abstract Wnt signalling through Ξ²βcatenin plays a pivotal role during embryonic pattern formation, cell fate determination and tissue homeostasis in the adult organism. In the skin, as in many other tissues, Wnt/Ξ²βcatenin signalling can control lineage determination and differentiation. However,