## Abstract Mice carrying the nude mutation (nu/nu) lack a functioning thymus and do not contain detectable levels of immunocompetent T cells. We now report that nu/nu mice do have lymphocytes which can be activated __in vivo__ by heterologous erythrocytes and a Lyt‐1 T cell‐derived factor (interle
T-cell-derived helper factor allows in vivo induction of cytotoxic T cells in nu/nu mice
✍ Scribed by Wagner, Hermann; Hardt, Conny; Heeg, Klaus; Röllinghoff, Martin; Pfizenmaier, Klaus
- Book ID
- 109718034
- Publisher
- Nature Publishing Group
- Year
- 1980
- Tongue
- English
- Weight
- 373 KB
- Volume
- 284
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/284278a0
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The effect of T cell‐replacing factor (TRF) on B cells was studied in spleen cell cultures from athymic nu/nu mice with particular emphasis on its possible role in proliferation and/or differentiation of precursor cells. In contrast to B cell mitogens, such as lipopolysaccharide, TRF d
Although the athymic nude mouse is grossly deficient in peripheral T cells, the number of lymphocytes bearing T-cell markers (L3T4, LyT2) and the alpha beta or gamma delta T-cell receptor (Tcr) increases steadily with age. The anatomical site(s) where these cells arise are unknown. Splenocytes from