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T cell dependence of B cell unresponsiveness in vitro

✍ Scribed by H. Waldmann; A. J. Munro

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
694 KB
Volume
4
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

Antigen‐specific high zone unresponsiveness to two thymus‐dependent antigens, TNP~560~KLH (2,4,6trinitrophenylkeyhole) limpet hemocyanin and TNP~6~FGG (2,4,6trinitrophenylfowl IgG), was induced in vitro. It was found that carrier recognition was required for its production, and that unresponsiveness was present at the level of B cells.

Thymus‐derived cells were required to induce the unresponsive state in B cells.

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