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T-cell costimulation via CD28-CD80/CD86 and CD40-CD40 ligand interactions

✍ Scribed by C. Somoza; L.L. Lanier


Book ID
116158156
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
616 KB
Volume
146
Category
Article
ISSN
0923-2494

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Although CD28 triggering provides an important co-stimulatory signal to T cells, blocking the CD80/CD86 -CD28 interaction with CTLA-4lg fusion protein is not sufficient for tolerance induction in vivo or in vitro. According to more recent data, interruption of the CD40 -CD154 interaction might compl