T-Cell Antigen Receptor-alpha Chain Transmembrane Peptides: Correlation between Structure and Function
โ Scribed by Marina Ali; Noeris K. Salam; Michael Amon; Veronika Bender; David E. Hibbs; Nicholas Manolios
- Book ID
- 106452088
- Publisher
- Springer Netherlands
- Year
- 2006
- Tongue
- English
- Weight
- 320 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1573-3149
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Core peptide (CP; GLRILLLKV) is a 9โamino acid peptide derived from the transmembrane sequence of the Tโcell antigen receptor (TCR) ฮฑโsubunit. CP inhibits Tโcell activation both __in vitro__ and __in vivo__ by disruption of the TCR at the membrane level. To elucidate CP interactions wit
## Abstract Persistence is a hallmark of infection by viruses such as HIV, hepatitis B virus, hepatitis C virus and LCMV. In the case of LCMV, persistence may often be associated with exhaustion of CD8^+^ T cells. We demonstrate here that persistent antigen suppressed ILโ7Rฮฑ expression and this cor