Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation
✍ Scribed by Karl S. Lang; Mike Recher; Alexander A. Navarini; Nicola L. Harris; Max Löhning; Tobias Junt; Hans Christian Probst; Hans Hengartner; Rolf M. Zinkernagel
- Book ID
- 102168700
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 297 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Persistence is a hallmark of infection by viruses such as HIV, hepatitis B virus, hepatitis C virus and LCMV. In the case of LCMV, persistence may often be associated with exhaustion of CD8^+^ T cells. We demonstrate here that persistent antigen suppressed IL‐7Rα expression and this correlated with T cell exhaustion and reduced expression of the anti‐apoptotic molecule B cell leukemia/lymphoma 2 (Bcl‐2). In contrast, exposure to short‐lived antigen only temporarily suppressed IL‐7Rα expression, failed to induce T cell exhaustion, and primed T cells. Persistent antigen also suppressed IL‐7Rα expression on primed T cells and this correlated with exhaustion of a previously stable primed T cell population. These findings suggest that antigen longevity regulates T cell fate.