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T-cell acute lymphoblastic leukemia following therapy of rhabdomyosarcoma

✍ Scribed by Kaplinsky, Chaim ;Frisch, Amos ;Cohen, Ian J. ;Goshen, Yacov ;Jaber, Lutfi ;Yaniv, Isaar ;Stark, Batia ;Tamary, Hanah ;Zaizov, Rina

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 420 KB
Volume: 20
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950200310

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✦ Synopsis

Abstract

Multiple studies have documented an increased risk of secondary malignancies in patients receiving alkylating agents. Secondary leukemia following chemotherapy accounts for about 20% of all secondary neoplasms; most are acute nonlymphocytic. Secondary acute lymphoblastic leukemia has rarely been reported in either adult or childhood cancer. We report the development of acute T‐cell lymphoblastic leukemia in a child following successful treatment of a paravertebral embryonal rhabdomyosarcoma (ERS). Southern blot analysis of DNA extracted from the T‐cell lymphoblasts, using probes homologous to loci on the short arm of chromosome 11; P‐calcitonin, P40.1 and H‐ras, did not demonstrate the chromosomal loss of heterozygosity (LOH), a common feature of embryonal rhabdomyosarcoma. The data presented support the assumption that de novo leukemia emerged following treatment of the primary malignancy. © 1992 Wiley‐Liss, Inc.

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