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T-B-SCIDs and Omenn's syndrome: Three disorders of the V(D)J recombination

✍ Scribed by D. Moshous; B. Corneo; A. Barraud; N. Nicolas; M. Cavazzana-Calvo; R. de Chasseval; F. Le Deist; A. Fischer; J.P. de Villartay

Book ID: 117326034
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 258 KB
Volume: 35
Category: Article
ISSN: 0161-5890
DOI: 10.1016/s0161-5890(98)90349-2

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## Abstract The third complementarity‐determining region (CDR) of the TCR α and β chains forms loops that engage amino acid residues of peptides complexed with MHC. This interaction is central to the specific discrimination of antigenic‐peptide–MHC complexes by the TCR. The TCRβ chain CDR3 loop is