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Influence of the V(D)J recombination mechanism on the formation of the primary T and B cell repertoires

✍ Scribed by Ann J. Feeney; Kimberly D. Victor; Kiem Vu; Bertrand Nadel; Reginald U. Chukwuocha

Book ID
115647753
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
478 KB
Volume
6
Category
Article
ISSN
1044-5323

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T cell receptor CDR3 loop length reperto
T cell receptor CDR3 loop length repertoire is determined primarily by features of the V(D)J recombination reaction
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## Abstract The third complementarity‐determining region (CDR) of the TCR α and β chains forms loops that engage amino acid residues of peptides complexed with MHC. This interaction is central to the specific discrimination of antigenic‐peptide–MHC complexes by the TCR. The TCRβ chain CDR3 loop is