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Systemic thermochemotherapy: Toxicity and plasma pharmacokinetics of methotrexate and doxorubicin

✍ Scribed by John M. Daly; Y.M. Wang; David Kapelanski; O. Howard Frazier


Book ID
116009804
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
436 KB
Volume
37
Category
Article
ISSN
0022-4804

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The influence of ranitidine on the pharmacokinetics and toxicity of doxorubicin was studied in six female New Zealand white rabbits. Plasma pharmacokinetic data were first obtained from rabbits given 3 mg/kg doxorubicin. After 1 month, the same rabbits were treated with ranitidine, 2.5 mg/kg or 25 m