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Systemic mastocytosis associated with t(8;21) acute myeloid leukemia in a child: Detection of the D816A mutation of KIT

✍ Scribed by Miharu Yabe; Atsuko Masukawa; Shunichi Kato; Hiromasa Yabe; Naoya Nakamura; Hiromichi Matsushita


Book ID
112168247
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
164 KB
Volume
59
Category
Article
ISSN
1545-5009

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Mast cell disease (MCD), a proliferation of mast cells (MC), is occasionally associated with hematologic malignancies. Neoplastic MC have activating c-kit mutations. c-kit is a receptor tyrosine kinase required for the development, proliferation, and survival of MC. Interaction of c-kit with its lig